Fat's 'master switch found -- could we turn it off?
LONDON — Scientists have found that a gene linked to diabetes and cholesterol is a "master switch" that controls other genes found in fat in the body, and say it should help in the search for treatments for obesity-related diseases.
In a study published in the journal Nature Genetics, the British researchers said that since fat plays an important role in peoples' susceptibility to metabolic diseases like obesity, heart disease and diabetes, the regulating gene could be target for drugs to treat such illnesses.
"This is the first major study that shows how small changes in one master regulator gene can cause a cascade of other metabolic effects in other genes," said Tim Spector of King's College London, who led the study.
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This is really interesting and could really be helpful. A new scientific study in London has revealed the KFL14 gene is in fact a "master switch" gene. The gene has already been linked to Type 2 diabetes and cholesterol amounts in the body.KLF14 controls the behavior of other genes found within fat in the body.This can be a major breakthrough in the search for treatments for diabetes and other obesity related diseases. I found this here: Gene found to control obesity and diabetes. A great news for those people who are suffering from this particular diseases.
When a gene sits atop a signaling cascade responsible for regulating multiple metabolic pathways in the human body, the chances of ever designing a drug to target that gene effectively without severe adverse side effects are slim-to-none.
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